| Primary Identifier | MGI:3803301 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Tnnt2 |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 13 was replaced with a floxed neo cassette and an exon 13 containing a deletion of three base pairs that results in the deletion of lysine at position 210 (K210). The neo cassette was removed by germ line, cre-mediated recombination. This mutation mimicks one identified in human patients with dilated cardiomyopathy. Similar levels of troponin T protein are detected in cardiac myofibrils isolated from the hearts of mice homozygous for this mutation and of wild-type mice by sodium dodecyl sulftate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis for total protein. |
