First Author | Lalanne JL | Year | 1983 |
Journal | Proc Natl Acad Sci U S A | Volume | 80 |
Issue | 24 | Pages | 7561-5 |
PubMed ID | 6143316 | Mgi Jnum | J:68862 |
Mgi Id | MGI:1933555 | Doi | 10.1073/pnas.80.24.7561 |
Citation | Lalanne JL, et al. (1983) Different exon-intron organization at the 5' part of a mouse class I gene is used to generate a novel H-2Kd-related mRNA. Proc Natl Acad Sci U S A 80(24):7561-5 |
abstractText | A cDNA library constructed from liver mRNA of DBA/2 (H-2d) mice has been screened with H-2-specific probes. The nucleotide sequence of one clone (pH-2d-24) indicates that it derives from an H-2 gene with an unexpected exon-intron organization. Nucleotide sequence comparisons suggest that two distinct mRNAs are produced from a single H-2Kd gene by a mechanism involving the use of alternative splicing sites in its 5' region. pH-2d-24 carries an open reading frame encoding a thus-far-undescribed polypeptide product identical to an H-2Kd-molecule, except for the NH2-terminal half of the first domain. |