| Primary Identifier | MGI:2442682 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 239436 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein homodimerization activity and zinc ion transmembrane transporter activity. Involved in several processes, including insulin processing; insulin secretion; and intracellular zinc ion homeostasis. Acts upstream of or within zinc ion transmembrane transport. Located in cytoplasmic vesicle. Is active in secretory granule membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced islet zinc levels, circulating insulin levels, and glucose-stimulated insulin secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
