| First Author | Ito S | Year | 2002 |
| Journal | Biochim Biophys Acta | Volume | 1576 |
| Issue | 3 | Pages | 341-5 |
| PubMed ID | 12084582 | Mgi Jnum | J:77756 |
| Mgi Id | MGI:2182521 | Doi | 10.1016/s0167-4781(02)00281-6 |
| Citation | Ito S, et al. (2002) Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim Biophys Acta 1576(3):341-5 |
| abstractText | We have identified a novel mouse gene klph (Klotho-LPH related protein; where LPH stands for lactase-phlorizin hydrolase) that encodes a novel mammalian family 1 glycosidase-like protein. KLPH was a putative type I membrane protein that consists of N-terminal signal sequence, glycosidase domain, transmembrane region and short cytoplasmic tail. Despite its overall structural similarity to other family 1 glycosidases, the glutamic acid for the acid-base catalyst was not conserved in this protein. klph mRNA was predominantly expressed in the kidney and skin. Epitope-tagged KLPH was localized to the perinuclear tubular network structure of the endoplasmic reticulum in cultured cells. |
