| Type | MGI:General | Description | in culture, mutant CD4+CD8+ double-positive thymocytes show increased sensitivity to cell death induced by mTNF (10 ng/ml) alone or in combination with cycloheximide relative to control (wild-type and heterozygous) thymocytes mutant hematopoietic precursors are highly sensitive to TNF-induced death: only very few or no erythroid and myeloid colonies develop from mutant fetal livers, whereas colonies from control fetal livers are only mildly suppressed mutant thymocytes are more sensitive than control cells to human TNF- or anti-TNFR1-induced cell death in the presence of cycloheximide whereas wild-type MEFs are resistant to treatment with mTNF plus cycloheximide, similarly-treated mutant MEFs start dying as early as 6 hrs, with only 15%-40% surviving by 24 hrs after treatment notably, treatment with anti-Fas antibody or dexamethasone reduces the viability of mutant thymocytes to a similar extent as in wild-type thymocytes |
