| First Author | Torres RM | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 5 | Pages | 527-36 |
| PubMed ID | 10591178 | Mgi Jnum | J:110760 |
| Mgi Id | MGI:3641017 | Doi | 10.1016/s1074-7613(00)80128-4 |
| Citation | Torres RM, et al. (1999) A negative regulatory role for Ig-alpha during B cell development. Immunity 11(5):527-36 |
| abstractText | The development of B cells requires the expression of an antigen receptor at distinct points during maturation. The Ig-alpha/beta heterodimer signals for these receptors, and mice harboring a truncation of the Ig-alpha intracellular domain (mb-1(delta(c)/delta(c)) have severely reduced peripheral B cell numbers. Here we report that immature mb-1(delta(c)/delta(c) B cells are activated despite lacking a critical Ig-alpha-positive signaling motif. As a consequence of abnormal activation, transitional immature IgMhighIgDlow B cells are largely absent in mb-1delta(c)/delta(c) mutants, accounting for the paucity of mature B cells. Thus, Ig-alpha cytoplasmic tail truncation yields an antigen receptor complex on immature B cells that signals constitutively. These data illustrate a role for Ig-alpha in negatively regulating antigen receptor signaling during B cell development. |
