| First Author | Gibbons DL | Year | 2009 |
| Journal | PLoS One | Volume | 4 |
| Issue | 4 | Pages | e5401 |
| PubMed ID | 19404390 | Mgi Jnum | J:148252 |
| Mgi Id | MGI:3844153 | Doi | 10.1371/journal.pone.0005401 |
| Citation | Gibbons DL, et al. (2009) Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS One 4(4):e5401 |
| abstractText | BACKGROUND: Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood. METHODOLOGY/PRINCIPAL FINDINGS: Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-ras(G12D) and p53(R172H). We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature. CONCLUSIONS/SIGNIFICANCE: These findings provide evidence that K-ras(G12D); p53(R172H) mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents. |
