First Author | Chen CK | Year | 1996 |
Journal | Proc Natl Acad Sci U S A | Volume | 93 |
Issue | 23 | Pages | 12885-9 |
PubMed ID | 8917514 | Mgi Jnum | J:36569 |
Mgi Id | MGI:83997 | Doi | 10.1073/pnas.93.23.12885 |
Citation | Chen CK, et al. (1996) RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A 93(23):12885-9 |
abstractText | G proteins regulate intracellular signaling by coupling a cycle of guanine nucleotide binding and hydrolysis to transient changes of cellular functions. The mechanisms that control the recycling of transducin, the pacesetting G protein that regulates mammalian phototransduction, are unclear. We show that a novel retinal specific RGS-motif protein specifically binds to an intermediate conformation involved in GTP hydrolysis by transducin and accelerates phosphate release and the recycling of transducin. This specific interaction further rationalizes the kinetics of the phototransduction cascade and provides a general hypothesis to explain the mechanism of interaction of RGS proteins with other G proteins. |