| First Author | Li B | Year | 2003 |
| Journal | Mol Endocrinol | Volume | 17 |
| Issue | 11 | Pages | 2365-76 |
| PubMed ID | 12907756 | Mgi Jnum | J:86313 |
| Mgi Id | MGI:2679395 | Doi | 10.1210/me.2003-0023 |
| Citation | Li B, et al. (2003) Compromised reproductive function in adult female mice selectively expressing mutant ErbB-1 tyrosine kinase receptors in astroglia. Mol Endocrinol 17(11):2365-76 |
| abstractText | The ErbB-1 tyrosine kinase receptor plays critical roles in regulating physiological functions. This receptor-mediated signaling in astroglia has been implicated in controlling female sexual development via activating neurons that release LH-releasing hormone (LHRH), the neuropeptide required for the secretion of LH. It remains unknown whether astroglial ErbB-1 receptors are necessary for maintaining normal adult reproductive function. Here we provide genetic evidence that astroglia-specific and time-controlled disruption of ErbB-1 receptor signaling by expressing mutant ErbB-1 receptors leads to compromised reproduction due to alteration in LHRH neuron-controlled secretion of LH in adult female mice. Therefore, astroglial ErbB-1 receptors are required for controlling LHRH neuronal function and thus maintaining adult reproduction, suggesting that compromised astroglial ErbB-1 signaling may also contribute to reproductive abnormalities in aging females. |
