| First Author | von Wegerer J | Year | 2003 |
| Journal | Neurosci Lett | Volume | 345 |
| Issue | 1 | Pages | 45-8 |
| PubMed ID | 12809985 | Mgi Jnum | J:107528 |
| Mgi Id | MGI:3621380 | Doi | 10.1016/s0304-3940(03)00499-3 |
| Citation | von Wegerer J, et al. (2003) Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic. Neurosci Lett 345(1):45-8 |
| abstractText | Inhibitory glycine receptor (GlyR) and GABA(A) receptor (GABA(A)R)-mediated synaptic transmission was examined in two strains of the GlyR mutant mouse spastic and the respective wild types. The mutants display a mild and a severe neurological phenotype. Electrically evoked postsynaptic whole-cell currents were recorded from alpha-motoneurons in lumbar spinal cord slices. Amplitudes of GlyR-mediated IPSCs were significantly reduced in the severe phenotype in comparison to the respective wild type and the mild phenotype mutants. Surprisingly, amplitudes of GABA(A)R-mediated IPSCs were also significantly reduced in both mutants. Fast time constants of the decay phase of IPSCs were slightly reduced for the GlyR-mediated IPSCs and significantly larger for the GABA(A)R-mediated IPSCs in both mutant strains. |
