| Primary Identifier | IPR044539 | Type | Family |
| Short Name | Pch2-like |
| description | This entry represents a group of AAA ATPases, including Pch2 from eukaryotes. It is required for the meiotic checkpoint that prevents chromosome segregation when recombination and chromosome synapsis are defective []. In humans it is linked to Mosaic variegated aneuploidy syndrome 3 (MVA3) [].This entry also includes a group of uncharacterised AAA domain-containing proteins from bacteria, including Cap6 (also known as TRIP13) from Pseudomonas aeruginosa. Cap6 is a homologue of Pch2. It is part of the CBASS (cyclic oligonucleotide-based antiphage signaling system) and functions as an AAA+ ATPase that prevents the CdnD:Cap7:Cap8 complex from synthesizing 2',3',3'-cyclic AMP-AMP-AMP (cAAA), which is a second messenger []. Cap6 binds and disassembles the active CD-NTase:HORMA complex, and hence functions as a negative regulator of CBASS []. |
