| First Author | Sims JE | Year | 2000 |
| Journal | J Exp Med | Volume | 192 |
| Issue | 5 | Pages | 671-80 |
| PubMed ID | 10974033 | Mgi Jnum | J:64348 |
| Mgi Id | MGI:1889125 | Doi | 10.1084/jem.192.5.671 |
| Citation | Sims JE, et al. (2000) Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J Exp Med 192(5):671-80 |
| abstractText | Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated from a thymic stromal cell line. This factor, termed thymic stromal lymphopoietin (TSLP), is a protein of 140 amino acids. The gene encoding TSLP was mapped to murine chromosome 18. Purified recombinant TSLP supported the growth of pre-B cell colonies in vitro, but had no myelopoietic activity. TSLP had comitogenic activity for fetal thymocytes, but was not as potent as interleukin 7 in lobe submersion cultures. Injection of TSLP into neonatal mice induced the expansion of B220(+)BP-1(+) pre-B cells. |
