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Protein Coding Gene : Rttn rotatin
Primary Identifier  MGI:2179288 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  246102
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Acts upstream of or within determination of left/right symmetry. Predicted to be located in centrosome and membrane. Predicted to be active in centriole and ciliary basal body. Is expressed in several structures, including branchial arch; embryo mesoderm; extraembryonic component; forelimb bud; and neural ectoderm. Orthologous to human RTTN (rotatin).
PHENOTYPE: Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart. [provided by MGI curators]
  • synonyms:
  • Rttn,
  • MGI:2441910,
  • RIKEN cDNA C530033I08 gene,
  • RIKEN cDNA 4921538A15 gene,
  • expressed sequence AI666264,
  • MGI:2147258,
  • AI666264,
  • MGI:1918209,
  • 4921538A15Rik,
  • rotatin,
  • C530033I08Rik
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