First Author | Saris CJ | Year | 1986 |
Journal | Cell | Volume | 46 |
Issue | 2 | Pages | 201-12 |
PubMed ID | 3013423 | Mgi Jnum | J:8318 |
Mgi Id | MGI:56786 | Doi | 10.1016/0092-8674(86)90737-3 |
Citation | Saris CJ, et al. (1986) The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell 46(2):201-12 |
abstractText | We have isolated and sequenced a full-length cDNA clone for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain). This sequence predicts a 339 amino acid (Mr 38,493) protein containing an N-terminal region of 20 amino acids, known to interact with a 10 kd protein (light chain), and a C-terminal region, found to contain two Ca2+/phospholipid-binding sites, that can be aligned as four 70 amino acid repeats. A single p36 gene was detected in the mouse genome, and a major p36 mRNA of 1.6 kb was found to be expressed in different mouse tissues. Unexpectedly, p36 and the phospholipase A2 inhibitor lipocortin I were found to be 50% identical in sequence over the C-terminal 300 residues. The function of p36 and its relation to other proteins are discussed. |