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Protein Coding Gene : Adam28 a disintegrin and metallopeptidase domain 28
Primary Identifier  MGI:105988 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  13522
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Is expressed in foregut; nasal cavity epithelium; respiratory system; and thymus. Human ortholog(s) of this gene implicated in breast cancer; estrogen-receptor positive breast cancer; invasive ductal carcinoma; lung adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human ADAM28 (ADAM metallopeptidase domain 28).
PHENOTYPE: Homozygous knockout increases metastatic pulmonary colonization after injection with tumor cells as a result of reduced pulmonary CD8+ T cell invasion. [provided by MGI curators]
  • synonyms:
  • a disintegrin and metallopeptidase domain 28,
  • Adam28,
  • RIKEN cDNA C130072N01 gene,
  • MDC-L,
  • MGD-MRK-33668,
  • MGI:2443863,
  • D430033C21Rik,
  • Dtgn1,
  • MGI:2442612,
  • C130072N01Rik,
  • RIKEN cDNA D430033C21 gene,
  • disintegrin 1
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1 Involved In Mutations

Trail: ProteinCodingGene

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