| First Author | Hippen KL | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 2 | Pages | 909-16 |
| PubMed ID | 16002689 | Mgi Jnum | J:100671 |
| Mgi Id | MGI:3589290 | Doi | 10.4049/jimmunol.175.2.909 |
| Citation | Hippen KL, et al. (2005) In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance. J Immunol 175(2):909-16 |
| abstractText | In normal B cell development, a large percentage of newly formed cells bear receptors with high levels of self-reactivity that must be tolerized before entry into the mature B cell pool. We followed the fate of self-reactive B cells expressing high affinity anti-hen egg lysozyme (HEL) Ag receptors exposed in vivo to membrane HEL in a setting in which the anti-HEL L chain was 'knocked-in' at the endogenous L chain locus. These mice demonstrated extensive and efficient L chain receptor editing responses and had B cell numbers comparable to those found in animals lacking membrane Ag. BrdU labeling indicated that the time required for editing in response to membrane HEL was approximately 6 h. In mice transgenic for soluble HEL, anti-HEL B cells capable of editing showed evidence for both editing and anergy. These data identify receptor editing as a major physiologic mechanism by which highly self-reactive B cells are tolerized to membrane and soluble self-Ags. |
