| First Author | Pereira LV | Year | 2000 |
| Journal | Gene | Volume | 255 |
| Issue | 2 | Pages | 363-71 |
| PubMed ID | 11024297 | Mgi Jnum | J:65097 |
| Mgi Id | MGI:1891774 | Doi | 10.1016/s0378-1119(00)00313-9 |
| Citation | Pereira LV, et al. (2000) X-chromosome inactivation: lessons from transgenic mice. Gene 255(2):363-71 |
| abstractText | X-chromosome inactivation (XCI) is the process by which mammals perform dosage compensation of X-linked gene products between XY males and XX females, resulting in the transcriptional silencing of all but one X chromosome per diploid cell. XCI involves counting the X chromosomes in a cell, randomly choosing those to be inactivated, spreading the inactivation signal in cis throughout the chromosome, and maintaining the inactive state of those X chromosomes during cell divisions thereafter. How the cell performs all these tasks is a fascinating problem and, together with epigenetic inheritance, a basic cellular mechanism that remains to be fully understood. In this review, we describe recent experiments aimed at understanding the first events of XCI and propose a model for initiation of XCI. |
