| First Author | Feunteun J | Year | 1997 |
| Journal | Horm Res | Volume | 47 |
| Issue | 4-6 | Pages | 137-9 |
| PubMed ID | 9167944 | Mgi Jnum | J:40870 |
| Mgi Id | MGI:892553 | Doi | 10.1159/000185456 |
| Citation | Feunteun J, et al. (1997) Targeted oncogenesis in the thyroid of transgenic mice. Horm Res 47(4-6):137-9 |
| abstractText | We have developed mouse models for tumors affecting the epithelial cellular compartment of the thyroid which has been targeted using the bovine thyroglobulin (bTg) promoter. Transgenic mice expressing the human activated c- Ha-Ras gene developed papillary thyroid carcinomas demonstrating the oncogenic potential of activated Ras gene in the thyroid gland. Transgenic mice express the mutant form of the a subunit of the adenylate cyclase- coupled G alpha(s) with mutations at codon 201 (R201H). The expression of this mutant transgene is not by itself sufficient to produce benign tumors or even hyperplasia, but the transgenic mice have inherited a predisposition to develop thyroid adenomas. |
