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Publication : Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development.

First Author  Collin L Year  2007
Journal  Exp Cell Res Volume  313
Issue  13 Pages  2946-57
PubMed ID  17544395 Mgi Jnum  J:142941
Mgi Id  MGI:3822438 Doi  10.1016/j.yexcr.2007.05.003
Citation  Collin L, et al. (2007) Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development. Exp Cell Res 313(13):2946-57
abstractText  Oligodendrocytes (OLs) are the glial cells of the central nervous system (CNS) classically known to be devoted to the formation of myelin sheaths around most axons of the vertebrate brain. We have addressed the role of these cells during cerebellar development, by ablating OLs in vivo. Previous analyses had indicated that OL ablation during the first six postnatal days results into a striking cerebellar phenotype, whose major features are a strong reduction of granule neurons and aberrant Purkinje cells development. These two cell types are highly interconnected during cerebellar development through the production of molecules that help their proliferation, differentiation and maintenance. In this article, we present data showing that OL ablation has major effects on the physiology of Purkinje (PC) and granule cells (GC). In particular, OL ablation results into a reduction of sonic hedgehog (Shh), Brain Derived Neurotrophic Factor (BDNF), and Reelin (Rln) expression. These results indicate that absence of OLs profoundly alters the normal cerebellar developmental program.
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