| First Author | Tsai CH | Year | 2023 |
| Journal | Cell Metab | Volume | 35 |
| Issue | 1 | Pages | 118-133.e7 |
| PubMed ID | 36599297 | Mgi Jnum | J:332546 |
| Mgi Id | MGI:7427284 | Doi | 10.1016/j.cmet.2022.12.003 |
| Citation | Tsai CH, et al. (2023) Immunoediting instructs tumor metabolic reprogramming to support immune evasion. Cell Metab 35(1):118-133.e7 |
| abstractText | Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early-stage tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by non-canonical interferon gamma (IFNgamma)-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment. |
