| First Author | Kiyokawa H | Year | 1992 |
| Journal | Proc Natl Acad Sci U S A | Volume | 89 |
| Issue | 6 | Pages | 2444-7 |
| PubMed ID | 1372445 | Mgi Jnum | J:2283 |
| Mgi Id | MGI:50807 | Doi | 10.1073/pnas.89.6.2444 |
| Citation | Kiyokawa H, et al. (1992) Cloning of a D-type cyclin from murine erythroleukemia cells. Proc Natl Acad Sci U S A 89(6):2444-7 |
| abstractText | We report the complete coding sequence of a cDNA, designated CYL2, derived from a murine erythroleukemia cell library. CYL2 is considered to encode a D-type cyclin because (i) there is cross hybridization with CYL1 (a murine homolog of human cyclin D1) and the encoded protein has 64% amino acid sequence identity with CYL1 and (ii) murine erythroleukemia cell-derived CYL2 contains an amino acid sequence identical to that previously reported for the C-terminal portion of a partially sequenced CYL2. Transcripts of murine erythroleukemia cell CYL2 undergo alternative polyadenylylation like that of human cyclin D1. A major 6.5-kilobase CYL2 transcript changes its expression during the cell cycle with a broad peak through G1 and S phases and a decrease in G2/M phases. The present findings suggest that CYL2 plays a role in the G1 to S phase progression. |
