| First Author | Fujii Y | Year | 1994 |
| Journal | Cell Immunol | Volume | 155 |
| Issue | 2 | Pages | 335-44 |
| PubMed ID | 8181070 | Mgi Jnum | J:18807 |
| Mgi Id | MGI:67031 | Doi | 10.1006/cimm.1994.1127 |
| Citation | Fujii Y, et al. (1994) Bcl-2 expression in the thymus and periphery. Cell Immunol 155(2):335-44 |
| abstractText | Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regulated only in the CD1+, CD3- to low, CD4+8+ thymocytes, and the B cells that are in cell cycle in the tonsil and lymph node. In contrast, the CD2+, CD1-3-4-8-19-, early T cells, and mature single positive cells in the thymus, as well as the tonsilar and lymph node T cells, irrespective of their cell cycle status, expressed bcl-2. These results are consistent with the notion that bcl-2 is down-regulated in the T and B cells that are in the process of generating new antigen receptors and subject to subsequent positive selection. |
