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Publication : Genetic control of resistance to trypanosomiasis.

First Author  Kemp SJ Year  1996
Journal  Vet Immunol Immunopathol Volume  54
Issue  1-4 Pages  239-43
PubMed ID  8988870 Mgi Jnum  J:98907
Mgi Id  MGI:3580722 Doi  10.1016/s0165-2427(96)05692-9
Citation  Kemp SJ, et al. (1996) Genetic control of resistance to trypanosomiasis. Vet Immunol Immunopathol 54(1-4):239-43
abstractText  To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.
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