| First Author | DePoy LM | Year | 2013 |
| Journal | Behav Brain Res | Volume | 243 |
| Pages | 171-5 | PubMed ID | 23327740 |
| Mgi Jnum | J:197156 | Mgi Id | MGI:5490943 |
| Doi | 10.1016/j.bbr.2013.01.004 | Citation | DePoy LM, et al. (2013) Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity. Behav Brain Res 243:171-5 |
| abstractText | Prefrontal cortical dendritic spine remodeling during adolescence may open a window of vulnerability to pathological stimuli that impact long-term behavioral outcomes, but causal mechanisms remain unclear. We administered the Rho-kinase inhibitor HA-1077 during three adolescent periods in mice to destabilize dendritic spines. In adulthood, cocaine-induced locomotor activity was exaggerated. By contrast, when administered in adulthood, HA-1077 had no psychomotor consequences and normalized food-reinforced instrumental responding after orbitofrontal-selective knockdown of Brain-derived neurotrophic factor, a potential factor in addiction. Thus, early-life Rho-kinase inhibition confers cocaine vulnerability, but may actually protect against pathological reward-seeking - particularly in cases of diminished neurotrophic support - in adulthood. |
