| Primary Identifier | IPR037640 | Type | Domain |
| Short Name | SMOC2_EC |
| description | SMOC-2 is a ubiquitously expressed matricellular protein that enhances the response to angiogenic growth factors, mediate cell adhesion, keratinocyte migration, and metastasis [, ]. It is also associated with vitiligo and craniofacial and dental defects []. Moreover, SMOC-2 acts as an Arf1 GTPase-activating protein (GAP) that interacts with clathrin heavy chain (CHC) and clathrin assembly protein CALM and functions in the retrograde, early endosome/trans-Golgi network (TGN) pathway in a clathrin- and AP-1-dependent manner []. SMOC-2 contains a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs. This entry represents the EC domain []. |
