| First Author | Wu Z | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 16 | Pages | 2459-67 |
| PubMed ID | 22710123 | Mgi Jnum | J:186426 |
| Mgi Id | MGI:5432301 | Doi | 10.1016/j.febslet.2012.06.004 |
| Citation | Wu Z, et al. (2012) Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2. FEBS Lett 586(16):2459-67 |
| abstractText | miR-21 has been shown to regulate multiple mRNAs and cause tumor progression and metastasis. However, whether miR-21-mediated posttranscriptional regulation is involved in antigen presentation and anti-mycobacterial responses remains unclear. Here, we report that miR-21 can be induced after Bacillus Calmette-Guerin (BCG) vaccination by NF-kB activation. miR-21 suppressed IL-12 production by targeting IL-12p35, which impaired anti-mycobacterial T cell responses both in vitro and in vivo. Additionally, miR-21 also promoted dendritic cell (DC) apoptosis by targeting Bcl-2. Therefore, miR-21 may potentially be involved in fine-tuning of the anti-mycobacterial Th1 response and in regulating the efficacy of BCG vaccination. |
