| Primary Identifier | IPR045330 | Type | Family |
| Short Name | Trm3/TARBP1 |
| description | This entry includes a group of putative methyltransferases, including TARBP1 from humans and Trm3 from Saccharomyces cerevisiae. TARBP1 (TAR RNA-binding protein 1) plays a role in HIV-1 infection by binding to the loop region of TAR RNA, a region also bound by RNA polymerase II [, , ]. Its dimerization may have a critical role in its activity []. Trm3 catalyses a specific methylation of the guanosine nucleotide at position 18 of the tRNAs. It is involved in the cellular response to oxidative stress, and its activity may play a role on innate response [, ]. |
