| First Author | Mahuzier A | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 2279 |
| PubMed ID | 29891944 | Mgi Jnum | J:267879 |
| Mgi Id | MGI:6209354 | Doi | 10.1038/s41467-018-04676-w |
| Citation | Mahuzier A, et al. (2018) Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Nat Commun 9(1):2279 |
| abstractText | Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia, nucleated from centrioles, persist once formed and withstand the forces produced by the external fluid flow and by their own cilia beating. Here, we show that a dense actin network around the centrioles is induced by cilia beating, as shown by the disorganisation of the actin network upon impairment of cilia motility. Moreover, disruption of the actin network, or specifically of the apical actin network, causes motile cilia and their centrioles to detach from the apical surface of ependymal cell. In conclusion, cilia beating controls the apical actin network around centrioles; the mechanical resistance of this actin network contributes, in turn, to centriole stability. |
