Primary Identifier | MGI:1915115 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 67865 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled acetylcholine receptor signaling pathway. Predicted to act upstream of or within negative regulation of signal transduction. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and nuclear body. Is expressed in central nervous system; dorsal root ganglion; early conceptus; and secondary oocyte. Orthologous to human RGS10 (regulator of G protein signaling 10). PHENOTYPE: A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton. [provided by MGI curators] |