| First Author | Benoist CO | Year | 1983 |
| Journal | Cell | Volume | 34 |
| Issue | 1 | Pages | 169-77 |
| PubMed ID | 6309407 | Mgi Jnum | J:68092 |
| Mgi Id | MGI:1932033 | Doi | 10.1016/0092-8674(83)90147-2 |
| Citation | Benoist CO, et al. (1983) Regions of allelic hypervariability in the murine A alpha immune response gene. Cell 34(1):169-77 |
| abstractText | The murine Ia antigens, a group of cell surface glycoproteins, are involved in the control of the immune response. The structure of one of these class II major histocompatibility complex molecules, A alpha, was recently deduced from sequence analysis of a cDNA clone produced from k haplotype mice. We have now isolated and sequenced A alpha cDNA clones from five other mouse haplotypes: d, b, f, u, and q. Sequence comparison revealed a surprisingly high degree of allelic polymorphism. Interestingly, amino acid substitutions were clustered within the first external domain of this polypeptide chain, particularly at a few highly variable positions. Functional implications of A alpha polymorphism and possible mechanisms for its generation are discussed. |
