Primary Identifier | MGI:3843458 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Avp |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A floxed neo cassette was inserted in intron 1 and an A(-1)T signal peptide mutation was inserted in exon 1 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. RT-PCR confirmed the expression of mutant transcript in the hypothalamus. |