| Primary Identifier | IPR035930 | Type | Homologous_superfamily |
| Short Name | FomD-like_sf |
| description | This β-barrel domain is found in FomD, a protein encoded in the fosfomycin biosynthesis gene cluster [, ], which hydrolyzes (S)-HPP-CMP to give (S)-HPP and CMP in the presence of Mn2 or Co2 []. FomD also hydrolyzes cytidylyl 2-hydroxyethylphosphonate (HEP-CMP), which is a biosynthetic intermediate before C-methylation. FomD structure revealed that it has a β-barrel fold consisting of a large twisted antiparallel β-sheet, a key feature of DUF402-containing proteins. The function of this domain is unknown. It has a conserved Tyr residue which activates a water molecule to promote nucleophilic attack on the phosphorus atom of the phosphonate moiety []. This domain has been also found in Ntdp (nucleoside tri- and diphosphatase, also known as Sa1684) from Staphylococcus aureus []. |
