| Primary Identifier | IPR045593 | Type | Domain |
| Short Name | Atg11_middle |
| description | This domain represents a region comprised between residues 522 and 583 from fission yeast protein Atg11 (also known as Taz1-interacting factor 1). This domain is necessary and sufficient for Atg11 autophagy function and for supporting Atg1 kinase activity as it harbours an Atg1-binding domain at the N terminus and a homodimerization domain at the C terminus. The N-terminal part of this domain contains the conserved aromatic residues Phe and Tyr necessary for the direct and specific interaction with the tMIT domain of Atg1. This interaction is required for the autophagy function of Atg11. The C-terminal part of this domain, residues 546-583, is predicted to adopt a coiled-coil conformation which mediates Atg11 homodimerization []. Proteins containing this domain seem to be restricted to Schizosaccharomyces. |
