Primary Identifier | IPR037890 | Type | Family |
Short Name | KMT2D |
description | Histone-lysine N-methyltransferase 2D (KMT2D, also known as MLL2; ) is a catalytic component of the MLL2/3 complex (also named ASCOM complex) []and methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D is recruited by ESR1 and acts as a coactivator of the oestrogen receptor alpha []. |