| Primary Identifier | MGI:1859212 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 54123 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to symbiont; positive regulation of macromolecule biosynthetic process; and regulation of toll-like receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; central nervous system; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). PHENOTYPE: Homozygous null mice are more vulnerable to viral infection and exhibit decreased serum interferon levels in response to viral infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
