| First Author | Aurrand-Lions M | Year | 1996 |
| Journal | Immunity | Volume | 5 |
| Issue | 5 | Pages | 391-405 |
| PubMed ID | 8934567 | Mgi Jnum | J:37066 |
| Mgi Id | MGI:84472 | Doi | 10.1016/s1074-7613(00)80496-3 |
| Citation | Aurrand-Lions M, et al. (1996) Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Immunity 5(5):391-405 |
| abstractText | Migration of hematopoietic precursor cells to the thymus is shown to depend upon a novel molecule called Vanin-1 expressed by perivascular thymic stromal cells. An anti-Vanin-1 antibody blocks the binding of pro-T cells to thymic sections in vitro, the in vivo accumulation of bone marrow cells around cortical thymic vessels, and long-term thymic regeneration. Thus, it interferes with the entry, and not the differentiation, of hematopoietic precursor cells. The Vanin-1 gene codes for a GPI-anchored 70 kDa protein that shows homology only with human biotinidase. Transfection of thymic stromal cells with the Vanin-1 cDNA enhances thymocyte adhesion in vitro. These data suggest that Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. |
