| First Author | Furukawa T | Year | 1997 |
| Journal | Cell | Volume | 91 |
| Issue | 4 | Pages | 531-41 |
| PubMed ID | 9390562 | Mgi Jnum | J:44489 |
| Mgi Id | MGI:1100293 | Doi | 10.1016/s0092-8674(00)80439-0 |
| Citation | Furukawa T, et al. (1997) Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell 91(4):531-41 |
| abstractText | We have isolated a novel otx-like homeobox gene, Crx, from the mouse retina. Crx expression is restricted to developing and mature photoreceptor cells. CRX bound and transactivated the sequence TAATCC/A, which is found upstream of several photoreceptor-specific genes, including the opsin genes from many species. Overexpression of Crx using a retroviral vector increased the frequency of clones containing exclusively rod photoreceptors and reduced the frequency of clones containing amacrine interneurons and Muller glial cells. In addition, presumptive photoreceptor cells expressing a dominant-negative form of CRX failed to form proper photoreceptor outer segments and terminals. Crx is a novel photoreceptor-specific transcription factor and plays a crucial role in the differentiation of photoreceptor cells. |
