| First Author | Kautz L | Year | 2014 |
| Journal | Nat Genet | Volume | 46 |
| Issue | 7 | Pages | 678-84 |
| PubMed ID | 24880340 | Mgi Jnum | J:211331 |
| Mgi Id | MGI:5574517 | Doi | 10.1038/ng.2996 |
| Citation | Kautz L, et al. (2014) Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet 46(7):678-84 |
| abstractText | Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease. |
