| Primary Identifier | MGI:2152844 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 117591 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within glucose transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including early conceptus; heart; liver; metanephros; and thymus primordium. Used to study abdominal obesity-metabolic syndrome and hyperuricemia. Orthologous to human SLC2A9 (solute carrier family 2 member 9). PHENOTYPE: Mice homozygous for a knock-out allele show partial prenatal lethality, polydipsia, hyperuricemia, hyperuricosuria and polyuria, and develop urate nephropathy, characterized by obstructive lithiasis, tubulointerstitial inflammation, cortical fibrosis, renal insufficiency and reduced male weight. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
