| First Author | Nowak EC | Year | 2009 |
| Journal | J Exp Med | Volume | 206 |
| Issue | 8 | Pages | 1653-60 |
| PubMed ID | 19596803 | Mgi Jnum | J:151590 |
| Mgi Id | MGI:4354471 | Doi | 10.1084/jem.20090246 |
| Citation | Nowak EC, et al. (2009) IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med 206(8):1653-60 |
| abstractText | We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6-producing macrophages in the central nervous system, as well as mast cell numbers in the regional lymph nodes. Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease. |
