| Type | MGI:General | Description | an increased number of barbell shaped-proplatelets (platelets with 2 cell bodies), which are normally very rare, is observed by TEM analysis % of barbell proplatelets is markeldy increased in freshly obtained washed platelets, in washed platelets cultured in suspension for 24 hours, and in washed platelets after perfusion over a vWF-coated microcapillary enrichment of barbell proplatelets suggests a defect in the scission required to produce mature platelets, possibly related to the abnormal membrane structure seen in megakaryocytes and platelets bone marrow transplantation experiments confirmed that enrichment in barbell-shaped proplatelets is due to a hematopoietic cell defect |
