| Primary Identifier | MGI:2144423 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 216831 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and neurotransmitter receptor transport, endosome to postsynaptic membrane. Located in dendritic spine. Is active in glutamatergic synapse. Is expressed in central nervous system; olfactory epithelium; respiratory system; and retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased brain weight, abnormal dendritic spine morphology, hypoactivity, increased self-grooming behavior, abnormal response to novel objects, and impaired motor learning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
