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Protein Coding Gene : Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Primary Identifier  MGI:2147274 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  106952
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables GTPase activator activity. Predicted to be involved in signal transduction. Predicted to be located in cell projection; cytoskeleton; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in blood vessel and embryo. Orthologous to human ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3).
PHENOTYPE: Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects. [provided by MGI curators]
  • synonyms:
  • AI851258,
  • centaurin, delta 3,
  • Arap3,
  • MGI:2444395,
  • DRAG1,
  • expressed sequence AI851258,
  • E030006K04Rik,
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3,
  • RIKEN cDNA E030006K04 gene,
  • Centd3
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Trail: ProteinCodingGene

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Disease

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