| Primary Identifier | MGI:101841 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 19043 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of defense response to virus; negative regulation of interferon-beta production; and regulation of signal transduction. Located in cytosol and membrane. Is expressed in several structures, including blastocyst; early embryo; gonad; liver; and lung. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). PHENOTYPE: Homozygous KO results in early pre-implantation lethality. A hypomorphic mutation results in increased sensitivity to Tnf-induced necroptosis and early death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
