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Protein Coding Gene : Isg15 ISG15 ubiquitin-like modifier
Primary Identifier  MGI:1855694 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  100038882
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables protein tag activity. Involved in several processes, including ISG15-protein conjugation; defense response to other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; decidua; embryo; labyrinthine zone; and mesometrium. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier).
PHENOTYPE: Homozygous null mice are viable and fertile and do not display immunological abnormalities. [provided by MGI curators]
  • synonyms:
  • ISG15 ubiquitin-like modifier,
  • interferon-stimulated protein,
  • MGI:3809535,
  • Isg15,
  • 100038882,
  • G1p2,
  • predicted gene, 100038882,
  • interferon, alpha-inducible protein
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