Primary Identifier | IPR007668 | Type | Domain |
Short Name | RFX1_trans_act |
description | The RFX family is a family of winged-helix DNA-binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is found N-terminal to the RFX DNA-binding region () in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analysis has identified the region 233-351 in human RFX1 () as being required for maximal activation []. |