| Primary Identifier | MGI:2442572 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 106504 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ion binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; postsynapse organization; and protein modification process. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection and altered TLR9-activated inflammatory responses. Mice homozygous for a different knock-out allele exhibit mislocalization of opsin, increased apoptosis and proliferation of photoreceptors in the inner nuclear layer and disrupted localization of amacrine cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
