| Primary Identifier | MGI:4943782 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Lrrk2 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A targeting vector was designed to replace exons 39-40 of the leucine-rich repeat kinase 2 (Lrrk2) gene with a loxP-flanked neomycin resistance (neo) cassette. Correctly targeted ES cells were transiently transfected with a Cre recombinase expression plasmid to delete the neo cassette. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred to C57BL/6NTac mice. |
