| First Author | Serizawa I | Year | 2000 |
| Journal | Cytokine | Volume | 12 |
| Issue | 6 | Pages | 630-5 |
| PubMed ID | 10843738 | Mgi Jnum | J:62975 |
| Mgi Id | MGI:1860178 | Doi | 10.1006/cyto.2000.0669 |
| Citation | Serizawa I, et al. (2000) Long-term overexpression of human granulocyte colony-stimulating factor in transgenic mice: persistent neutrophilia with no increased mortality for more than one year. Cytokine 12(6):630-5 |
| abstractText | To investigate possible adverse consequences of persistent neutrophil overproduction, mice transgenic for human granulocyte colony-stimulating factor (hG-CSF) were studied for more than 1 year. They showed marked granulocytopoiesis and neutrophilia. Continuous medullary and extramedullary granulocytopoiesis resulted in marked changes in bone and liver. In the liver, haemorrhage and focal necrosis and a few haemangiosarcomas were present, presumably caused by the destructive granulocytopoiesis. Despite the high incidence of lung infiltration by mature neutrophils, lung lesions rarely appeared. Although there was a persistent increase in neutrophils, mortality of the mice did not differ from that of non-transgenic littermates at least within 1 year after birth. Factors other than overproduction of G-CSF and extensive neutrophilia could be required for the development of neutrophil-mediated acute and chronic tissue damage. Copyright 2000 Academic Press. |
