| Primary Identifier | IPR004763 | Type | Family |
| Short Name | CzcA/CusA/SilA/NccA/HelA/CnrA |
| description | This family consists of the H+/heavy metal cation antiporters. CzcA has a low cation transport activity for cobalt and is essential for the expression of cobalt, zinc and cadmium resistance. CusA is a part of a cation efflux system that mediates resistance to copper and silver [, ]. NccA is a component of the NCC cation-efflux system that confers resistance to nickel, cobalt and cadmium. It may form a membrane tunnel, which allows ion transport across the membrane. SilA is a component of the sil cation-efflux system that confers resistance to silver. It may be part of a three-component cation/proton antiporter.HelA is presumed to function with HelC and HelB in efflux of an unidentified substrate.The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter. |
